کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2047593 | 1074004 | 2014 | 8 صفحه PDF | دانلود رایگان |
• MiR-106b is up-regulated in CAFs compared to NFs in gastric cancer.
• Down-regulation of miR-106b in CAFs inhibits cancer cell motility by targeting PTEN.
• MiR-106b might be a potential therapeutic target for gastric cancer.
It is well established that the interaction between cancer cells and microenvironment has a critical role in tumor development, but the roles of miRNAs in this interaction are rarely known. Here, we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer, the expression level of miR-106b is associated with poor prognosis of patients, and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN. Taken together, these data suggest that miR-106b might be a novel candidate target for the treatment of gastric cancer.
Journal: FEBS Letters - Volume 588, Issue 13, 13 June 2014, Pages 2162–2169