کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047618 1074006 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages
چکیده انگلیسی


• Ox-LDL increases the levels of DKK1 via LXRα and β-catenin in macrophages.
• DKK1 inhibits lipid accumulation in macrophages.
• DKK1 increases the levels of ABCA/G1 via STAT3 pathway.

Dickkopf1 (DKK1), a canonical Wnt/β-catenin pathway antagonist, is closely associated with cardiovascular disease and adipogenesis. We performed an in vitro study to determine whether oxidized low-density lipoprotein (ox-LDL) increased the expression of DKK1 in macrophages and whether β-catenin and liver X receptor α (LXRα) were involved in this regulation. Induction of DKK1 expression by ox-LDL decreased the level of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) via a Wnt/β-catenin pathway and increased ATP-binding cassette transporter A/G1 (ABCA/G1) levels via a signal transducer and activator of transcription 3 (STAT3) pathway. Lower LOX-1 and higher ABCA/G1 levels inhibited cholesterol loading in macrophages. In conclusion, ox-LDL may induce DKK1 expression in macrophages to inhibit the accumulation of lipids through a mechanism that involves downregulation of LOX-1-mediated lipid uptake and upregulation of ABCA/G1-dependent cholesterol efflux.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 1, 2 January 2015, Pages 52–58
نویسندگان
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