کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2047816 | 1074036 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ceramide kinase deficiency improves diet-induced obesity and insulin resistance Ceramide kinase deficiency improves diet-induced obesity and insulin resistance](/preview/png/2047816.png)
Ceramide kinase (CERK) is an enzyme that phosphorylates ceramide to produce ceramide 1-phosphate. Recently, evidence has emerged that CERK has a role in inflammatory signaling of immune cells. Since obesity is accompanied by chronic, low-grade inflammation, we examined whether CERK might be involved using CERK-null mice. We determined that CERK deficiency suppresses diet-induced increases in body weight, and improves glucose intolerance. Furthermore, we demonstrated that CERK deficiency attenuates MCP-1/CCR2 signaling in macrophages infiltrating the adipose tissue, resulting in the suppression of inflammation in adipocytes, which might otherwise lead to obesity and diabetes.
► CERK deficiency suppressed diet-induced obesity.
► CERK deficiency suppressed diet-induced swelling of adipocytes.
► CERK deficiency suppressed diet-induced inflammation in adipose tissue.
► CERK deficiency decreased the infiltration of macrophages into adipose tissue.
► CERK deficiency impaired MCP-1/CCR2 signaling in macrophages.
Journal: FEBS Letters - Volume 586, Issue 9, 7 May 2012, Pages 1300–1305