Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade

► oxLDL induces ADMA accumulation in HUVEC-conditioned medium. ► HUVEC-conditioned medium induces VSMC migration via DDAH2/ADMA pathway. ► Exogenous ADMA directly induce VSMC migration. ► ADMA induces VSMC migration via p38 and ERK1/2 MAPK signaling transduction way.