کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048083 1074060 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High levels of Cellular Prion Protein improve astrocyte development
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
High levels of Cellular Prion Protein improve astrocyte development
چکیده انگلیسی

Prion protein (PrPC) has neuroprotective functions and herein we demonstrate that astrocytes from PrPC-over-expressing mice are more resistant to induced cell death than wild-type astrocytes. The Stress-Inducible-Protein 1 (STI1), a PrPC ligand, prevents cell death in both wild-type and PrPC-over-expressing astrocytes through the activation of protein-kinase-A. Cultured embryonic astrocytes and brain extracts from PrPC-over-expressing mice show higher glial fibrillary acidic protein expression and reduced vimentin and nestin levels when compared to wild-type astrocytes, suggesting faster astrocyte maturation in the former mice. Our data indicate that PrPC levels modulate astrocyte development, and that PrPC–STI1 interaction contributes to protect against astrocyte death.


► PrPC over-expression promotes resistance to death and early maturation of astrocytes.
► PrPC interacts with STI1 and induces astrocyte survival through the PKA pathway.
► ERK1/2 activity is increased in PrPC over-expressing astrocytes.
► PrPC levels regulate GFAP, vimentin and nestin expression during brain development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 2, 16 January 2013, Pages 238–244
نویسندگان
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