کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048113 1074063 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression
چکیده انگلیسی

Gap junctional intercellular communication (GJIC) regulates cellular homeostasis by propagating signaling molecules, exchanging cellular metabolites, and coupling electrical signals. In cancer, cells exhibit altered rates of GJIC which may play a role in neoplastic progression. KATP channels help maintain membrane polarity and linkages between KATP channel activity and rates of GJIC have been established. The mechanistic relationship has not been fully elucidated. We report the effects of treatment with multiple KATP antagonist compounds on GJIC in metastatic cell lines demonstrating an increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of KATP. These effects remained consistent using cell lines with different expression levels of SUR1 and SUR2, suggesting possible off target effects on GJIC by these compounds.


► In this study we report the effects of KATP inhibitors on gap junction activity.
► Gap junction communication has been linked to the activity of KATP channels.
► KATP inhibitors with SUR2 specificity increase gap junction communication.
► We demonstrate these effects are independent of SUR2 expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 1, 2 January 2012, Pages 27–31
نویسندگان
, , , , , , , , ,