کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048191 1074069 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
چکیده انگلیسی

Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR). PCSK9 and LDLR are also expressed in insulin-producing pancreatic islet β cells, possibly affecting the function of these cells. Here we show that, compared to control mice, PCSK9-null male mice over 4 months of age carried more LDLR and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose-intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. Collectively, these observations suggest that PCSK9 may be necessary for the normal function of pancreatic islets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 4, 19 February 2010, Pages 701–706
نویسندگان
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