کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048321 | 1074076 | 2012 | 5 صفحه PDF | دانلود رایگان |
In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
► GPR84 has been identified as a receptor for medium-chain fatty acids (MCFAs).
► GPR84 appears in white adipose tissue during the onset of obesity.
► TNFα from macrophages enhances GPR84 expression.
► MCFAs down-regulate the anti-inflammatory cytokine adiponectin through GPR84.
► MCFA–GPR84 system may contribute to promote diabesity.
Journal: FEBS Letters - Volume 586, Issue 4, 17 February 2012, Pages 368–372