کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048345 | 1074077 | 2011 | 7 صفحه PDF | دانلود رایگان |
Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members.Structured summaryClaudin-25 and ZO-1colocalize by fluorescence microscopy(View interaction)ZO-1 and Claudin-26colocalize by fluorescence microscopy(View interaction)
Journal: FEBS Letters - Volume 585, Issue 4, 18 February 2011, Pages 606–612