کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048395 | 1074079 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts](/preview/png/2048395.png)
چکیده انگلیسی
Human islet amyloid polypeptide (hIAPP) is the primary component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus. However, it is unknown how amyloid fibrils are formed in vivo. In this study, we demonstrate that gangliosides play an essential role in the formation of amyloid deposits by hIAPP on plasma membranes. Amyloid fibrils accumulated in ganglioside- and cholesterol-rich microscopic domains (‘lipid rafts’). The depletion of gangliosides or cholesterol significantly reduced the amount of amyloid deposited. These results clearly showed that the formation of amyloid fibrils was mediated by gangliosides in lipid rafts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 17, 3 September 2009, Pages 2854–2858
Journal: FEBS Letters - Volume 583, Issue 17, 3 September 2009, Pages 2854–2858
نویسندگان
Masaki Wakabayashi, Katsumi Matsuzaki,