کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048449 | 1074081 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane](/preview/png/2048449.png)
چکیده انگلیسی
A cytotoxic peptide, polytheonamide B (pTB), from marine sponge was examined for cytotoxic spectrum and specific activity to mammalian cells was demonstrated. pTB is composed of alternative D- and L-amino acid residues throughout the 48-mer peptide. This suggests the formation of a β-helix similar to gramicidin channels. Planar bilayer experiments revealed that pTB forms monovalent cation-selective channels, being compatible with the inner pore diameter of ∼4 Å for a β-helical structure. pTB penetrated vectorially into the membrane, formed a channel by means of a single molecule, and remained in the membrane. These functional properties may account for specific cytotoxic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 18, 24 September 2010, Pages 3995–3999
Journal: FEBS Letters - Volume 584, Issue 18, 24 September 2010, Pages 3995–3999
نویسندگان
Masayuki Iwamoto, Hirofumi Shimizu, Ikunobu Muramatsu, Shigetoshi Oiki,