کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048469 1074081 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
چکیده انگلیسی

Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles in tumorigenesis are not entirely clear. Here, we reported the up-regulation of miR-24 in TSCC. MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. The direct targeting of miR-24 to the DND1 mRNA was predicted bioinformatically and confirmed by luciferase reporter gene assays. Furthermore, the miR-24-mediated change in DND1 expression suppressed the expression of cyclin-dependent kinase inhibitor 1B (CDKN1B), and also led to enhanced proliferation and reduced apoptosis in TSCC cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 18, 24 September 2010, Pages 4115–4120
نویسندگان
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