کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048516 | 1074082 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells](/preview/png/2048516.png)
miR-20a is an important member of the miR-17–92 cluster, and its real function in cervical cancer cells is unknown. Our study demonstrated that miR-20a was upregulated in cervical cancer tissues. Overexpression of miR-20a in cervical cancer-derived cell lines, HeLa and C-33A, enhanced long-term cellular proliferation, migration and invasion, whereas inhibition of miR-20a suppressed those functions. We also confirmed that oncogenic TNKS2 is directly upregulated by miR-20a. Furthermore, suppression of TNKS2 expression could inhibit colony formation, migration and invasion of cervical cancer cells. Therefore, we concluded that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.
► We demonstrated that miR-20a is upregulated in cervical cancer tissues.
► miR-20a promoted migration and invasion in HeLa and C-33A cells.
► Our results show that TNKS2 is directly upregulated by miR-20a.
► Knockdown of TNKS2 could inhibit colony formation, migration and invasion.
Journal: FEBS Letters - Volume 586, Issue 6, 23 March 2012, Pages 897–904