کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048606 | 1074084 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P](/preview/png/2048606.png)
چکیده انگلیسی
The effects of the sensory neurotransmitter substance P on the expression of tight junction proteins and on barrier function in human corneal epithelial cells were investigated. The expression of ZO-1, but not that of occludin or claudin-1, was increased by substance P in a concentration- and time-dependent manner. This effect was inhibited by the NK-1 receptor antagonist GR82334 and by KN62, an inhibitor of Ca2+- and calmodulin-dependent protein kinase II. Substance P also increased the transepithelial electrical resistance of a cell monolayer in a manner sensitive to GR82334. Substance P may therefore play a role in maintenance of tight junctions in the corneal epithelium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 12, 18 June 2009, Pages 2148–2153
Journal: FEBS Letters - Volume 583, Issue 12, 18 June 2009, Pages 2148–2153
نویسندگان
Ji-Ae Ko, Ryoji Yanai, Teruo Nishida,