کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048628 1074086 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel effects of CCN3 that may direct the differentiation of chondrocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Novel effects of CCN3 that may direct the differentiation of chondrocytes
چکیده انگلیسی

Identification and characterization of local molecules directing the differentiation of chondrocytes to either transient or permanent cartilage are major issues in cartilage biology. Here, we found CCN family protein 3 (CCN3) was abundantly produced in rat developing epiphyseal cartilage. Evaluations in vitro showed that CCN3 repressed epiphyseal chondrocyte proliferation, while promoting matrix production in multiple assays performed. Furthermore, CCN3 enhanced the articular chondrocytic phenotype; whereas it repressed the one representing endochondral ossification. Additionally, the phenotype of growth plate chondrocytes and chondrogenic progenitors also appeared to be affected by CCN3 in a similar manner. These findings suggest a significant role of CCN3 in inducing chondrocytes to articular ones during joint formation.


► CCN3 protein is abundantly produced in developing epiphyseal cartilage in long bones.
► CCN3 represses cell growth, but promotes proteoglycan accumulation.
► CCN3 has a significant role in the differentiation towards articular chondrocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 19, 3 October 2011, Pages 3033–3040
نویسندگان
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