کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048731 | 1074096 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of a cofilin-like actin-binding site on translationally controlled tumor protein (TCTP)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of a cofilin-like actin-binding site on translationally controlled tumor protein (TCTP) Identification of a cofilin-like actin-binding site on translationally controlled tumor protein (TCTP)](/preview/png/2048731.png)
چکیده انگلیسی
Translationally controlled tumor protein (TCTP) expression is suppressed during cancer cell reversion to a non-malignant phenotype. We identified a primary sequence of TCTP with homology to ADF/cofilin. We confirm that a synthetic peptide corresponding to this sequence binds specifically to actin and is displaced from actin by cofilin. TCTP peptide has higher affinity for G-actin than F-actin and does not block actin-filament depolymerization by cofilin. These results suggest that TCTP may channel active cofilin to F-actin, enhancing the cofilin-activity cycle in invasive tumor cells. Loss of TCTP may result in sequestration of active cofilin by a monomeric pool of actin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 23, 1 December 2010, Pages 4756–4760
Journal: FEBS Letters - Volume 584, Issue 23, 1 December 2010, Pages 4756–4760
نویسندگان
Katsiaryna Tsarova, Elena G. Yarmola, Michael R. Bubb,