کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048732 1074096 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone
چکیده انگلیسی

Herein, we show that intraerythrocytic stages of Plasmodium falciparum have an active pathway for biosynthesis of menaquinone. Kinetic assays confirmed that plasmodial menaquinone acts at least in the electron transport. Similarly to Escherichia coli, we observed increased levels of menaquinone in parasites kept under anaerobic conditions. Additionally, the mycobacterial inhibitor of menaquinone synthesis Ro 48-8071 also suppressed menaquinone biosynthesis and growth of parasites, although off-targets may play a role in this growth-inhibitory effect. Due to its absence in humans, the menaquinone biosynthesis can be considered an important drug target for malaria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 23, 1 December 2010, Pages 4761–4768
نویسندگان
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