کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048763 1074099 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beyond ribosome rescue: tmRNA and co-translational processes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Beyond ribosome rescue: tmRNA and co-translational processes
چکیده انگلیسی

tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 2, 21 January 2010, Pages 413–419
نویسندگان
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