کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048775 1074100 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future
چکیده انگلیسی

Signaling through the T cell receptor for antigen (TCR) has been studied for years by conventional biochemical means. More recently, attempts have been made to develop computational models of signaling through this receptor, with a specific focus on understanding how this recognition system discriminates between closely related (self and non-self) ligands. Here we discuss recent advances centered on the role of feedback regulation, especially the key finding that a combination of digital and analog control circuits is fundamental to the discrimination properties of the TCR. We end by pointing to future, more biologically accurate models that incorporate spatial aspects of molecular organization in antigen-engaged T lymphocytes with this underlying biochemistry.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 24, 15 December 2010, Pages 4814–4822
نویسندگان
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