کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048780 1074100 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The space and time frames of T cell activation at the immunological synapse
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The space and time frames of T cell activation at the immunological synapse
چکیده انگلیسی

The selective recognition of antigenic peptides by T cells requires the spatio/temporal integration of a panoply of molecular triggers. The space frame of T cell antigen receptors (TCR) interaction with peptide/MHC complexes (pMHC) displayed by antigen presenting cells is delineated by the micrometer-scale area of the immunological synapse. The time frame of T cell stimulation is governed by a series of short TCR–pMHC interactions that are integrated into sustained signaling leading to productive activation. We discuss here how approaching antigen recognition from the time and space angles is key to the comprehension of the puzzling process of T cell activation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 24, 15 December 2010, Pages 4851–4857
نویسندگان
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