کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2048914 | 1074106 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: The role of intracellular [Ca2+] Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: The role of intracellular [Ca2+]](/preview/png/2048914.png)
Maitotoxin (MTX), a potent polyether marine biotoxin, induces Ca2+ entry in different mammalian cells by activation of Ca2+ channels. The identity and modulation of the MTX-activated Ca2+ entry pathway is not known. In this work, we show, for the first time, that glucose and lactate can modulate the excitability of spermatogenic cell MTX-activated Ca2+ channels. Physiological and pharmacological evidences indicate that glucose and lactate differentially affect MTX-activated Ca2+ entry mainly through changes that these substrates induce on intracellular Ca2+ stores and the concentration of intracellular Ca2+ ([Ca2+]i) in spermatogenic cells. Our findings strongly suggest that MTX-activated Ca2+ channels in spermatogenic cells can be regulated by a Ca2+-CaM-dependent protein kinase.
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3111–3115