کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048929 | 1074106 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Domain compatibility in Ire1 kinase is critical for the unfolded protein response
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Domain compatibility in Ire1 kinase is critical for the unfolded protein response Domain compatibility in Ire1 kinase is critical for the unfolded protein response](/preview/png/2048929.png)
چکیده انگلیسی
The unfolded protein response is a mechanism to cope with endoplasmic reticulum stress. In Saccharomycescerevisiae, Ire1 senses the stress and mediates a signaling cascade to upregulate responsive genes through an unusual HAC1 mRNA splicing. The splicing requires interconnected activity (kinase and endoribonuclease (RNase)) of Ire1 to cleave HAC1 mRNA at the non-canonical splice sites before translation into Hac1 transcription factor. Analysis of the truncated kinase domain from Ire1 homologs revealed that this domain is highly conserved. Characterization by domain swapping indicated that a functional ATP/ADP binding domain is minimally required. However the overall domain compatibility is critical for eliciting its full RNase function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3203–3208
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3203–3208
نویسندگان
Juthakorn Poothong, Pattarawut Sopha, Randal J. Kaufman, Witoon Tirasophon,