کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049002 | 1074109 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway](/preview/png/2049002.png)
چکیده انگلیسی
We report here that alpha-lipoic acid (α-LA), a naturally-occurring antioxidant, scavenges reactive oxygen species (ROS) followed by an increase in apoptosis of human hepatoma cells. Apoptosis induced by α-LA was dependent upon the activation of the caspase cascade and the mitochondrial death pathway. α-LA induced increases in caspase-9 and caspase-3 but had no significant effect on caspase-8 activity. Apoptosis induced by α-LA was found to be mediated through the tensin homologue deleted on chromosome 10 (PTEN)/Akt pathway. Prior to cell apoptosis, PTEN was activated and its downstream target Akt was inhibited. Our findings indicate that increasing ROS scavenging could be a therapeutic strategy to treat cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 12, 28 May 2008, Pages 1667–1671
Journal: FEBS Letters - Volume 582, Issue 12, 28 May 2008, Pages 1667–1671
نویسندگان
Dong-yun Shi, Hong-lei Liu, Jeremy S. Stern, Pei-zhong Yu, Shan-lin Liu,