کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049005 | 1074109 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H2O2-induced premature senescence and interplay with p38αMAPK
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کلمات کلیدی
MAPK, mitogen-activated kinaseHDF, human diploid fibroblastGAPDH, glyceraldehyde-3-phosphate dehydrogenase - GAPDH، glyceraldehyde-3-phosphate dehydrogenaseMEM, minimum essential medium - MEM، حداقل حداقل لازم استmRNA, messenger Ribonucleic Acid - mRNA، messenger ریبونوکلئیک اسیدIgG, immunoglobulin G - ایمونوگلوبولین G، پادتن جیFBS, fetal bovine serum - سرم جنینی گاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H2O2-induced premature senescence and interplay with p38αMAPK Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H2O2-induced premature senescence and interplay with p38αMAPK](/preview/png/2049005.png)
چکیده انگلیسی
Treatment of IMR-90 human diploid fibroblasts with a sublethal concentration of H2O2 induces premature senescence. We investigated the protein abundance, subcellular localization and involvement of caveolin 1 in premature senescence. Caveolin 1 is a scaffolding protein able to concentrate and organize signaling molecules within the caveolae membrane domains. We report the first evidence of increased nuclear and cytoplasmic localization of caveolin 1 during establishment of H2O2-induced premature senescence. Moreover, we demonstrate that phosphorylation of caveolin 1 during treatment with H2O2 is dependent on p38α mitogen-activated protein kinase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 12, 28 May 2008, Pages 1685–1692
Journal: FEBS Letters - Volume 582, Issue 12, 28 May 2008, Pages 1685–1692
نویسندگان
Aline Chrétien, Neil Piront, Edouard Delaive, Catherine Demazy, Noëlle Ninane, Olivier Toussaint,