کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049044 | 1074113 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The amyloid fibrils of the constant domain of immunoglobulin light chain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The amyloid fibrils of the constant domain of immunoglobulin light chain The amyloid fibrils of the constant domain of immunoglobulin light chain](/preview/png/2049044.png)
چکیده انگلیسی
Light chain-associated (AL) amyloidosis is characterized by dominant fibril deposition of the variable domain (VL) of an immunoglobulin light chain, and thus its constant domain (CL) has been considered not to be amyloidogenic. We examined the in vitro fibril formation of the isolated CL in comparison with β2-microglobulin (β2-m), an immunoglobulin domain-like amyloidogenic protein responsible for dialysis-related amyloidosis. Two methods useful for β2-m at neutral pH also induced amyloid fibrils of CL, which were monitored by thioflavin-T binding and electron microscopy (EM). These results suggest that CL plays an important role, more than previously assumed, in the development of AL-amyloidosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 15, 4 August 2010, Pages 3348–3353
Journal: FEBS Letters - Volume 584, Issue 15, 4 August 2010, Pages 3348–3353
نویسندگان
Kaori Yamamoto, Hisashi Yagi, Young-Ho Lee, József Kardos, Yoshihisa Hagihara, Hironobu Naiki, Yuji Goto,