کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049098 1074116 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications
چکیده انگلیسی

Affibody molecules are a class of engineered affinity proteins with proven potential for therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 kDa) single domain proteins that can be isolated for high affinity and specificity to any given protein target. Fifteen years after its discovery, the Affibody technology is gaining use in many groups as a tool for creating molecular specificity wherever a small, engineering compatible tool is warranted. Here we summarize recent results using this technology, propose an Affibody nomenclature and give an overview of different HER2-specific Affibody molecules. Cumulative evidence suggests that the three helical scaffold domain used as basis for these molecules is highly suited to create a molecular affinity handle for vastly different applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 12, 18 June 2010, Pages 2670–2680
نویسندگان
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