کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049127 | 1074117 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
One SmpB molecule accompanies tmRNA during its passage through the ribosomes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: One SmpB molecule accompanies tmRNA during its passage through the ribosomes One SmpB molecule accompanies tmRNA during its passage through the ribosomes](/preview/png/2049127.png)
چکیده انگلیسی
tmRNA and SmpB are the main participants of trans-translation, a process which rescues the ribosome blocked during translation of non-stop mRNA. While a one-to-one stoichiometry of tmRNA to the ribosome is generally accepted, the number of SmpB molecules in the complex is still under question. We have isolated tmRNA–ribosome complexes blocked at different steps of the tmRNA path through the ribosome and analyzed the stoichiometry of the complexes. Ribosome, tmRNA and SmpB were found in equimolar amount in the tmRNA–ribosome complexes stopped at the position of the 2nd, 4th, 5th or the 11th codons of the coding part of the tmRNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 10, 30 April 2008, Pages 1532–1536
Journal: FEBS Letters - Volume 582, Issue 10, 30 April 2008, Pages 1532–1536
نویسندگان
Elizaveta Y. Bugaeva, Olga V. Shpanchenko, Brice Felden, Leif A. Isaksson, Olga A. Dontsova,