کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049147 1074118 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational prediction of nucleosome positioning by calculating the relative fragment frequency index of nucleosomal sequences
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Computational prediction of nucleosome positioning by calculating the relative fragment frequency index of nucleosomal sequences
چکیده انگلیسی

We developed an accurate method to predict nucleosome positioning from genome sequences by refining the previously developed method of Peckham et al. (2007) [19]. Here, we used the relative fragment frequency index we developed and a support vector machine to screen for nucleosomal and linker DNA sequences. Our twofold cross-validation revealed that the accuracy of our method based on the area under the receiver operating characteristic curve was 81%, whereas that of Peckham’s method was 75% when both of two nucleosomal sequence data obtained from independent experiments were used for validation. We suggest that our method is more effective in predicting nucleosome positioning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 8, 16 April 2010, Pages 1498–1502
نویسندگان
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