کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049206 1074120 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NEMO stabilizes c-Myc through direct interaction in the nucleus
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
NEMO stabilizes c-Myc through direct interaction in the nucleus
چکیده انگلیسی

The transcription factor c-Myc is a cellular oncoprotein generally upregulated in most of human cancers. NF-κB essential modulator (NEMO) caused phosphorylation and stabilization of c-Myc protein in the nucleus through direct interaction. The interaction caused reduced ubiquitination of c-Myc by inhibiting ubiquitinating activity of Fbw7 without blocking the interaction between c-Myc and Fbw7. As a consequence, NEMO enhanced the expression of several selected c-Myc targets. Compared to the classical role as an essential subunit for the activity of IKK complex, stabilization of c-Myc by direct interaction is a unique function of NEMO, representing a new mechanism to regulate c-Myc activity.Structured summaryMINT-8045088: c-Myc (uniprotkb:P01106) and NEMO (uniprotkb:Q9Y6K9) colocalize (MI:0403) by fluorescence microscopy (MI:0416)MINT-8045072, MINT-8045101: c-Myc (uniprotkb:P01106) physically interacts (MI:0915) with NEMO (uniprotkb:Q9Y6K9) by anti tag coimmunoprecipitation (MI:0007)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 22, 19 November 2010, Pages 4524–4530
نویسندگان
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