کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049223 1074120 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of the NLRP3 inflammasome by intracellular poly I:C
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Activation of the NLRP3 inflammasome by intracellular poly I:C
چکیده انگلیسی

Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 22, 19 November 2010, Pages 4627–4632
نویسندگان
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