کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049295 1074123 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane protein assembly into Nanodiscs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Membrane protein assembly into Nanodiscs
چکیده انگلیسی

Nanodiscs are soluble nanoscale phospholipid bilayers which can self-assemble integral membrane proteins for biophysical, enzymatic or structural investigations. This means for rendering membrane proteins soluble at the single molecule level offers advantages over liposomes or detergent micelles in terms of size, stability, ability to add genetically modifiable features to the Nanodisc structure and ready access to both sides of the phospholipid bilayer domain. Thus the Nanodisc system provides a novel platform for understanding membrane protein function. We provide an overview of the Nanodisc approach and document through several examples many of the applications to the study of the structure and function of integral membrane proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 9, 3 May 2010, Pages 1721–1727
نویسندگان
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