کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049417 1074127 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase
چکیده انگلیسی

C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 5, 5 March 2010, Pages 968–972
نویسندگان
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