کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2049434 | 1074127 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Positive contribution of the IRE1α–XBP1 pathway to placental expression of CEA family genes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Positive contribution of the IRE1α–XBP1 pathway to placental expression of CEA family genes Positive contribution of the IRE1α–XBP1 pathway to placental expression of CEA family genes](/preview/png/2049434.png)
چکیده انگلیسی
Inositol requiring enzyme-1α (IRE1α) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Recently, we showed that the IRE1α–XBP1 pathway plays an essential role in the placenta. However, details of its function remain unclear. To address this point, we searched for IRE1α- or XBP1-regulated genes in the placenta, and identified the CEA family as a novel target of the IRE1α–XBP1 pathway. Moreover, PSG genes, which also belong to the CEA family, were up-regulated by XBP1. We have therefore identified a new aspect of the physiological function of the IRE1α–XBP1 pathway in the placenta.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 5, 5 March 2010, Pages 1066–1070
Journal: FEBS Letters - Volume 584, Issue 5, 5 March 2010, Pages 1066–1070
نویسندگان
Daisuke Oikawa, Ryoko Akai, Takao Iwawaki,