کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2049482 | 1074130 | 2009 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Homocysteine and lipids: S-Adenosyl methionine as a key intermediate Homocysteine and lipids: S-Adenosyl methionine as a key intermediate](/preview/png/2049482.png)
An association between hyperlipidemia and hyperhomocysteinemia (HHCY) has been suggested. This link is clinically important in management of vascular risk factors especially in elderly people and patients with metabolic syndrome. Higher plasma homocysteine (Hcy) was associated with lower high-density lipoprotein (HDL)-cholesterol level. Moreover, HHCY was associated with disturbed plasma lipids or fatty liver. It seems that hypomethylation associated with HHCY is responsible for lipid accumulation in tissues. Decreased methyl group will decrease the synthesis of phosphatidylcholine, a major phospholipid required for very low-density lipoprotein (VLDL) assembly and homeostasis. The effect of Hcy on HDL-cholesterol is probably related to inhibiting enzymes or molecules participating in HDL-particle assembly.
Journal: FEBS Letters - Volume 583, Issue 8, 17 April 2009, Pages 1215–1225