کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049602 1074134 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Qualitatively distinct phenotypes in the design space of biochemical systems
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Qualitatively distinct phenotypes in the design space of biochemical systems
چکیده انگلیسی

Although characterization of the genotype has undergone revolutionary advances as a result of the successful genome projects, the chasm between our understanding of a fully characterized gene sequence and the phenotypic repertoire of the organism is as broad and deep as it was in the pre-genomic era. There are two fundamental unsolved problems that provide the context for the challenges in relating genotype to phenotype. We address one of these and describe a generic method for constructing a system design space in which qualitatively distinct phenotypes can be identified and counted, their relative fitness analyzed and compared, and their tolerance to change measured.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 24, 17 December 2009, Pages 3914–3922
نویسندگان
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