کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049643 1074137 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of SigT and RstA in the differentiation of Streptomyces coelicolor
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Involvement of SigT and RstA in the differentiation of Streptomyces coelicolor
چکیده انگلیسی

SigT is an ECF sigma factor in Streptomyces coelicolor. sigT and its putative anti-sigma factor gene rstA are located in one putative operon, and SigT could physically interact with RstA. Deletion of sigT or rstA caused accelerated morphological development and enhanced production of antibiotics, concomitant with over-expression of chpE, chpH, actII-orf4 and redD. Furthermore, SigT was undetectable after loss of rstA. These data suggested that SigT has a negative role on differentiation and that RstA negatively regulates the SigT activity through a putative antagonistic mechanism and at the post-transcriptional level.Structured summaryMINT-7262599, MINT-7262614: RstA (uniprotkb:Q9S6U2) physically interacts (MI:0915) with sigT (uniprotkb:O86856) by pull down (MI:0096)MINT-7262539: rpoC (uniprotkb:Q8CJT1) physically interacts (MI:0915) with sigT (uniprotkb:O86856) by pull down (MI:0096)MINT-7262574: RstA (uniprotkb:Q9S6U2) physically interacts (MI:0915) with sigT (uniprotkb:O86856) by anti tag coimmunoprecipitation (MI:0007)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 19, 6 October 2009, Pages 3145–3150
نویسندگان
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