کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2049877 | 1074146 | 2009 | 5 صفحه PDF | دانلود رایگان |
Kaempferol is a dietary flavonoid that is thought to function as a selective estrogen receptor modulator. In this study, we established that kaempferol also functions as an inverse agonist for estrogen-related receptors alpha and gamma (ERRα and ERRγ). We demonstrated that kaempferol binds to ERRα and ERRγ and blocks their interaction with coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Kaempferol also suppressed the expressions of ERR-target genes pyruvate dehydrogenase kinase 2 and 4 (PDK2 and PDK4). This evidence suggests that kaempferol may exert some of its biological effect through both estrogen receptors and estrogen-related receptors.Structured summary:MINT-6824653:PGC-1 alpha (uniprotkb:Q9UBK2) and ERR gamma (uniprotkb: P62508) bind (MI:0407) by surface plasmon resonance (MI:0107)
Journal: FEBS Letters - Volume 583, Issue 4, 18 February 2009, Pages 643–647