کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050005 | 1074150 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac](/preview/png/2050005.png)
Nitric oxide (NO), generated by NO synthases (NOSs), has multifarious roles in signal transduction. Reactive oxygen species (ROS), generated by ubiquitous NADPH oxidases (NOXs), also participate in cellular signaling. However, the coordination of signals conveyed by NO and ROS is poorly understood. We show that the small GTPase Rac, a component of some NOXs, also interacts with and regulates the constitutively-expressed NOSs. Cellular NO and O2- production increase or decrease together following activation or inhibition of Rac, and Rac inhibition reveals transduction mechanisms that depend upon NO (vasodilation), ROS (actin polymerization) or both (cytoskeletal organization). Thus, signaling by NO and ROS may be coordinated through a common control element.
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2195–2202