کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050013 | 1074150 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A short helix in the C-terminal region of LolA is important for the specific membrane localization of lipoproteins
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The structures of a lipoprotein carrier, LolA, and a lipoprotein receptor, LolB, are similar except for an extra C-terminal loop containing a 310 helix and β-strand 12 in LolA. Lipoprotein release was significantly reduced when β-12 was deleted. Deletion of the 310 helix also inhibited the lipoprotein release. Furthermore, lipoproteins were non-specifically localized to membranes when LolA lacked the 310 helix. Thus, the membrane localization of lipoproteins with the LolA derivative lacking the 310 helix was independent of LolB whereas LolB was essential for the outer membrane localization of lipoproteins with the wild-type LolA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2247–2251
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2247–2251
نویسندگان
Suguru Okuda, Shoji Watanabe, Hajime Tokuda,