کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050026 | 1074150 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation](/preview/png/2050026.png)
Recent studies show that human Pnas4 might be tumor associated, while its function remains unknown. Here, we investigate the developmental function of Pnas4 using zebrafish as a model system. Knocking down Pnas4 causes gastrulation defects with a shorter and broader axis, as well as a posteriorly mis-positioned prechordal plate, due to the defective convergence and extension movement. Conversely, over-expression of Pnas4 mRNA leads to an elongated body axis. We further demonstrate that Pnas4 is required cell-autonomously for dorsal convergence but not for anterior migration. In addition, genetic interaction assays indicate that Pnas4 might act in parallel with non-canonical Wnt signal in the regulation of cell movement. Our data suggest that Pnas4 is a key regulator of cell movement during gastrulation.
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2325–2332