کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050028 1074150 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes
چکیده انگلیسی

Inward rectifier potassium Kir2.x channels mediate cardiac inward rectifier potassium currents (IK1). As a subunit of Kir2.x, the physiological role of Kir2.3 in native cardiomyocytes has not been reported. This study shows that Kir2.3 knock-down remarkably down-regulates Kir2.3 expression (Kir2.3 protein was reduced to 19.91 ± 3.24% on the 2nd or 3rd day) and IK1 current densities (at −120 mV, control vs. knock-down: −5.03 ± 0.24 pA/pF, n = 5 vs. −1.16 ± 0.19 pA/pF, n = 7, P < 0.001) in neonatal rat cardiomyocytes. The data suggest that Kir2.3 plays a potentially important role in IK1 currents in neonatal rat cardiomyocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 15, 25 June 2008, Pages 2338–2342
نویسندگان
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