کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050110 | 1074153 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In silico structural analyses of sets of α-helical antimicrobial peptides (AMPs) are performed. Differences between hemolytic and non-hemolytic AMPs are revealed in organization of their N-terminal region. A parameter related to hydrophobicity of the N-terminal part is proposed as a measure of the peptide propensity to exhibit hemolytic and other unwanted cytotoxic activities. Based on the information acquired, a rational approach for selective removal of these properties in AMPs is suggested. A proof of concept is gained through engineering specific mutations that resulted in elimination of the hemolytic activity of AMPs (latarcins) while leaving the beneficial antimicrobial effect intact.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 14, 21 July 2009, Pages 2425–2428
Journal: FEBS Letters - Volume 583, Issue 14, 21 July 2009, Pages 2425–2428
نویسندگان
Anton A. Polyansky, Alexander A. Vassilevski, Pavel E. Volynsky, Olga V. Vorontsova, Olga V. Samsonova, Natalya S. Egorova, Nicolay A. Krylov, Alexei V. Feofanov, Alexander S. Arseniev, Eugene V. Grishin, Roman G. Efremov,