کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050111 | 1074153 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
3′-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 3′-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein 3′-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein](/preview/png/2050111.png)
چکیده انگلیسی
Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem cells, and is considered to be a stemness factor. A known function of Msi1 is translational repression of specifically bound mRNAs. Although the basic mechanism and some target RNAs have been reported, further survey of interactors is necessary to understand the integrated function of Msi1. By screening using an mRNA display technique, we found that doublecortin (dcx) mRNA is a specific binding target of Msi1 in vitro. We confirmed that Msil repressed translation of a luciferase reporter gene linked to the selected 3′-untranslated region fragment of dcx in Neuro2A cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 14, 21 July 2009, Pages 2429–2434
Journal: FEBS Letters - Volume 583, Issue 14, 21 July 2009, Pages 2429–2434
نویسندگان
Kenichi Horisawa, Takao Imai, Hideyuki Okano, Hiroshi Yanagawa,