کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050203 1074158 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation
چکیده انگلیسی

Rapid advances in DNA sequencing improve existing techniques and enable new approaches in genetics and functional genomics, bringing about unprecedented coverage, resolution and sensitivity. Enhanced toolsets can facilitate the untangling of connections between genomic variation, environmental factors and phenotypic effects, providing novel opportunities, but may also pose challenges in data interpretation, especially in highly heterogeneous human populations. Laboratory rodent strains, however, offer a variety of tailored model systems with controlled genetic backgrounds, facilitating complex genotype/phenotype relationship studies. In this review we discuss the advent of massively parallel sequencing, its methodological advantage for molecular analysis in model organisms and the expectation of increased understanding of biologically relevant consequences of human genetic variation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 11, 5 June 2009, Pages 1668–1673
نویسندگان
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