کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050240 1074162 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sendai virus F glycoprotein induces IL-6 production in dendritic cells in a fusion-independent manner
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Sendai virus F glycoprotein induces IL-6 production in dendritic cells in a fusion-independent manner
چکیده انگلیسی

We previously reported that inactivated Sendai virus particle (hemagglutinating virus of Japan envelope; HVJ-E) has anti-tumor effects by eliciting IL-6 production in dendritic cells (DCs). In the present study, we investigated which components of HVJ-E elicit IL-6 production. HVJ-E containing F0 protein inactive for virus envelope–cell membrane fusion enhanced IL-6 production. Reconstituted liposomes containing F protein stimulated IL-6 production. The antibody against F protein inhibited IL-6 secretion by HVJ-E. When carbohydrate chains of the F glycoprotein were removed, HVJ-E lost the ability to stimulate IL-6 secretion. These results suggest that F glycoprotein is required for IL-6 production in DCs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 9, 16 April 2008, Pages 1325–1329
نویسندگان
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