کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050320 | 1074164 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Uteroglobin suppresses allergen-induced TH2 differentiation by down-regulating the expression of serum amyloid A and SOCS-3 genes Uteroglobin suppresses allergen-induced TH2 differentiation by down-regulating the expression of serum amyloid A and SOCS-3 genes](/preview/png/2050320.png)
Allergen-induced airway inflammation may lead to allergic asthma, a chronic inflammatory disease of the respiratory system. Despite its high incidence, the majority of the world’s population is unaffected by allergic airway inflammation most likely due to innate protective mechanism(s) in the respiratory system. The mammalian airway epithelia constitutively express uteroglobin (UG), a protein with potent anti-inflammatory and anti-chemotactic properties. We report here that UG binds to FPR2, a G-protein coupled receptor, inhibits chemotaxis, down-regulates SOCS-3 gene expression and STAT-1 activation, which are critical for the differentiation of T-helper 2 (TH2) cells that secrete pro-inflammatory TH2 cytokines. We propose that UG suppresses allergen-mediated activation of TH2 response by down-regulating the expression of genes that are critical for TH2 differentiation.
Journal: FEBS Letters - Volume 580, Issue 25, 30 October 2006, Pages 6022–6026