کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050435 | 1074170 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel anticancer effect of butein: Inhibition of invasion through the ERK1/2 and NF-κB signaling pathways in bladder cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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چکیده انگلیسی
There is increasing evidence that epithelial–mesenchymal transition (EMT) plays a critical role in cancer metastasis. Butein is a polyphenolic compound, which has been found to exhibit anti-proliferation effects on cancer cells. Here, we report that in addition to its function as an anti-proliferation agent, butein can inhibit migration and invasion through the ERK1/2 and NF-κB signaling pathways in human bladder cancer cells, and this inhibitory effect may be associated with reversal of EMT. These results were further confirmed by RNAi-mediated suppression of NF-κB, which partly reverses EMT and inhibits cell invasive ability in vitro. These results suggest a novel function of butein as an invasion inhibitor in bladder cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 13, 11 June 2008, Pages 1821–1828
Journal: FEBS Letters - Volume 582, Issue 13, 11 June 2008, Pages 1821–1828
نویسندگان
LiRui Zhang, Wei Chen, Xu Li,