کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2050462 | 1074171 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histidine residues in the IS3–IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Histidine residues in the IS3–IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel Histidine residues in the IS3–IS4 loop are critical for nickel-sensitive inhibition of the Cav2.3 calcium channel](/preview/png/2050462.png)
چکیده انگلیسی
We recently reported that a histidine (H191) in the S3–S4 loop of domain I is critical for nickel inhibition of the Cav3.2 T-type Ca2+ channel. As in Cav3.2, two histidine residues are commonly found in the IS3–IS4 loops of mammalian Cav2.3 Ca2+ channels, which are also blocked by low micromolar concentrations of nickel. We show here by site-directed mutagenesis and electrophysiology that both residues contribute to the nickel sensitivity of Cav2.3, with H183 being more critical than H179. These findings strongly suggest that both H179 and H183 in the IS3–IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 30, 22 December 2007, Pages 5774–5780
Journal: FEBS Letters - Volume 581, Issue 30, 22 December 2007, Pages 5774–5780
نویسندگان
Ho-Won Kang, Hyung-Jo Moon, Seol-hee Joo, Jung-Ha Lee,