کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050564 1074174 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9
چکیده انگلیسی

We describe here the cloning and characterization of a novel mouse homeodomain-interacting protein kinase (HIPK)-like gene, Hipk4. Hipk4 is expressed in lung and in white adipose tissue and encodes a 616 amino acid protein that includes a serine/threonine kinase domain. We demonstrate that HIPK4 could phosphorylate human p53 protein at serine 9, both in vitro and in vivo. Among known p53-responsive promoters, activity of the human survivin promoter, which is repressed by p53, was decreased by HIPK4 in p53 functional A549 cells. Human BCL2-associated X protein-promoter activity was not affected. These findings suggest that phosphorylation of p53 at serine 9 is important for p53 mediated transcriptional repression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 29, 11 December 2007, Pages 5649–5657
نویسندگان
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