کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050671 1074177 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells
چکیده انگلیسی

Roscovitine is a potent CDK inhibitor often used as a biological tool in cell-cycle studies, but its working mechanism and real targets in vascular smooth muscle cells (VSMCs) remain unclear. In this study, we observed that ERK1/2 phosphorylation induced by Ang II was abrogated by pretreating VSMCs with roscovitine for 15 h. Pretreating VSMCs with roscovitine also inhibited Ang II-induced c-Jun expression and phosphorylation. We further demonstrated that roscovitine could suppress the DNA binding activity of c-Jun and activation of angiotensinogen promoter by Ang II. These results suggest that roscovitine represses Ang II-induced angiotensinogen expression by inhibiting activation of ERK1/2 and c-Jun.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 2, 23 January 2008, Pages 243–248
نویسندگان
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